We know that researchers are counting on us to provide compounds with impeccable purity and exact amino-acid sequencing
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The most effective way to treat a deficiency, other than reintegrating B12-rich foods into the diet, is through injection
The most common side effects are injection-site soreness (41%, lasting 24-36 hours), mild nausea (12-15%, lasting 4-8 hours), and skin flushing (8-10%, lasting 10-30 minutes)
You have the right to receive care and treatment that is appropriate to you, meets your needs and reflects your preferences
This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice